Mike Mendez directs this sci-fi comedy about an enormous alien spider that has escaped from a top-secret military lab. As the spider tears across the city of Los Angeles destroying everything and everyone in its way, it is left to two unlikely heroes to save the day. Exterminator Alex (Greg Grunberg) and security guard Jose (Lombardo Boyar) team up to trace the creature's movements in an attempt to stop it before it obliterates the city.